Research

Research Grants

NIH RO1 Research Grant: Global Health Innovations is partnering with the University of Kansas Medical Center (KUMC) and the Kenya Medical Research Institute (KEMRI) on a 5-year, NIH-funded research grant to rigorously evaluate the HITSystem in six hospitals in Kenya. Primary outcome measures will include retention at 9 and 18 months of age, linkage to treatment among HIV+ infants, turn-around time for PCR testing and communication of results, and meeting interventions such as OI prophylaxis and PCR testing by 6 weeks of age. Our study team will also conduct cost-effectiveness analyses to determine the costs of providing HIV EID services and potential savings achieved by the HITSystem. This study will provide important data for governments considering national scale-up of the HITSystem.

NIH R34 Research Grant: GHI is partnering again with the University of Kansas Medical Center (KUMC) and KEMRI for a 3-year NIH-funded grant in Kenya. We are adapting the HITSystem to support PMTCT retention and adherence in Kenya. Our goal is to adapt our HITSystem to support HIV-infected pregnant women in antenatal care appointment attendance, ART medication adherence, a hospital-based delivery and early infant enrollment in early infant diagnosis services.

Publications and Abstracts

GHI’s HIV/AIDS work with mothers and their babies in Africa has been published in the most respected peer-reviewed scientific journals on the globe. We also continue to present our latest data at the leading and largest HIV/AIDS and public health conferences.

  • If you text them, they will come: using the HIV infant tracking system to improve early infant diagnosis quality and retention in Kenya. AIDS. 2014 Jul;28 Suppl 3:S313-21.

    Implementation of the HITSystem was associated with more than a two-fold increase in both EID retention and initiation of ART among HIV-infected infants compared to historical controls. Furthermore, turn-around time for PCR test results significantly improved, and the time for ART initiation among HIV-infected infants was reduced from 38 to 7 median days. Notably, the HITSystem improved care in both the urban and peri-urban settings…READ MORE

  • Improving early infant HIV diagnosis in Kenya: study protocol of a cluster-randomized efficacy trial of the HITSystem. Implementation Science.2015, 10:96. DOI: 10.1186/s13012-015-0284-3.
  • Lessons learned from implementing the HIV Infant Tracking System (HITSystem) to improve early infant diagnosis of HIV outcomes in Kenya. Healthcare: The Journal of Delivery Science and Innovation (in press).
  • Progress Toward Eliminating Mother to Child Transmission of HIV in Kenya: Review of Treatment Guideline Uptake and Pediatric Transmission at Four Government Hospitals Between 2010 and 2012. AIDS & Behavior, 1-10. April, 2015.
  • Private and Public Partnership: a Model for a National HIV Early Infant Diagnosis Program in Haiti; 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Cape Town, South Africa. 2009.
  • Analysis of the optimal cut-point for HIV-p24 antigen testing to diagnose HIV infection in HIV-exposed children from resource-constrained settings. Journal of Clinical Virology. 2011 Apr: 50(4):388-41.
  • Evaluation of Reverse Transcription, Loop-mediated Isothermal Amplification Assay to Detect HIV-1 in Dried Blood Spot Samples from HIV-1 Exposed Children. 18th Conference on Retroviruses and Opportunistic Infections. 2011.
  • Improving Turn-around Time for HIV DNA PCR Lab Results for Early Infant Diagnosis in Kenya; 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Kuala Lumpur, Malaysia. 2013.
  • Adherence to the 2010 Treatment Guidelines for the Prevention of Mother-to-Child Transmission (PMTCT) of HIV in Kenya; 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Kuala Lumpur, Malaysia. 2013.
  • HIV Infant Tracking System (HITSystem) in Kenya; 10th Annual Global Health & Innovation Conference, Yale University, New Haven Connecticut. 2013.

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